This can happen with beta-blockers, diuretics, some types of birth control, antivirals, and antiseizure drugs (also known as anticonvulsants), among others. Medications: A side-effect of some classes of pharmaceutical drugs is high LDL.If you know of relatives with high cholesterol, be aware that you may be at higher risk. Genetics: High LDL can be an inherited condition and runs in families.Physical activity: Those that don't get enough exercise or are too sedentary are at risk of high LDL due to weight gain or excessive weight status.Weight status: Being overweight or obese causes increases in LDL levels, making weight management an integral part of managing this condition.Diet: Eating an excess of foods high in saturated fat and cholesterol, as in fatty cuts of meat, dairy products, bacon, cakes, sausages, and others, raises levels.Among these are PCSK9 inhibitors, which include Praluent (alirocumab), Repatha (evolocumab), and Leqvio (inclisiran) selective cholesterol absorption inhibitors like Zetia (ezemtimibe) ACL inhibitors, such as Nexletol (bempedoic acid), as well as omega 3 fatty acids and niacin. Other drugs: Several other drugs may be used to act directly on LDL levels.These include Antara, Tricor, and Fenoglide, which are all different names for fenofibrate. Fibrates: This class of drug is more effective in cutting down triglyceride levels and raising HDL, though it can also temper LDL.These drugs include Questran (cholestyramine), Colestid (colestipol), and WelChol (colesevelam Hcl). In turn, your liver is stimulated to produce more bile, using up cholesterol.
This is fatal if not treated immediately. Cardiac arrest: In very rare cases, high LDL, especially if it leads to CAD, can cause your heart to suddenly stop.As with other issues, this occurs due to clotting in arteries of the brain. Stroke: Another common complication of high LDL and its associated conditions is stroke, an attack due to the rapid death of brain cells.This condition, characterized by angina, breathing difficulties, among other symptoms, leads to cell death in this organ and is a medical emergency. Heart attack: Occlusion of the cardiac arteries leads to muscles in the heart not getting the oxygen they need.PAD: Partial or complete blockage of arteries outside of the heart, especially in the lower limbs, can lead to swelling, muscular weakness, inflammation, and pain, especially when active.If atherosclerosis blocks these, stroke can arise. Carotid artery disease: The carotid arteries are important arteries on each side of the neck.This can lead to heart attack, among other severe and potentially fatal complications. CAD: Leading to chest pains (angina), shortness of breath, heart palpitations, elevated heart rate, dizziness and nausea, sweating, and muscular weakness.
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